Niacinamide is a form of Vitamin B3. It is also called nicotinamide. In cells, it is the precursor of NAD+/NADP+.
NAD+/NADP+ is a crucial electron carrier molecule that maintains energy flowing to power cell repair and maintenance functions. Cell repair includes restoring the skin barrier integrity, powering cell activities and conducting DNA repair. Nicotinamide is the source of energy that supports gene expression, maintains mitochondrial function and provides the organism with energetic reserves for stress resistance.
In the skin, nicotinamide protects the DNA from oxidative injury and supports its repair (from ultraviolet light exposure). It decreases inflammation and improves healing processes. If buffers chronic organism stress and slows degenerative changes. Niacinamide has a significant role in regulating aging pathways and neurodegeneration.
Meat, fish, whole grains, legumes and nuts are sources of niacinamide. The NAD+, a critical substrate must be replenished, and as we age, supplementation is indicated. Niacinamide is frequently included in skin care products for topical use.
Oral supplementation for metabolic support is 250-500mg daily. Higher doses may be indicated when chronic inflammation is present, at times of skin regenerative procedures, or during physical or emotional stress. Adequate resources are more important in those patient with eczema or chronic skin conditions that alter skin balance and barrier function.
